Given the ability to bind to previously undruggable biological targets, bifunctional protein degrader therapeutics have generated significant enthusiasm within the medical science community, thereby, defining a new frontier in the field of medicine
LONDON, March 10, 2020 /PRNewswire/ -- Roots Analysis has announced the addition of the "Targeted Protein Degradation Market: Focus on Therapeutics and Technology Platforms (based on Degronimids, ENDTACs, Epichaperome Inhibitors, Hydrophobic Tags, IMiDs, LYTACs, Molecular Glues, PHOTACs, PROTACs, Protein Homeostatic Modulators, SARDs, SERDs, SNIPERs, and Specific BET and DUB Inhibitors), 2020-2030" report to its list of offerings.
The concept of targeted protein degradation presents revolutionary drug development opportunities and is anticipated to bring about a paradigm shift in modern healthcare. The first targeted protein degrader, called proteolysis targeting chimera (PROTAC), was developed about a decade ago. Presently, a variety of other such chemical entities and molecular glues are under investigation. In fact, certain pipeline candidates are already in the mid to late-phase trials and are anticipated to soon enter the market.
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Key Market Insights
Close to 90 protein degradation-based leads are currently under evaluation
Nearly 20% of pipeline drugs are in the clinical phase of development, while the rest are in the preclinical / discovery stage. At present, PROTACs account for more than 30% of the pipeline drugs.
More than 60% of development programs are focused on treating advanced oncological disorders
Most targeted protein degrader leads are being investigated for the treatment of breast cancer, colorectal cancer, and prostate cancer. This class of drugs is also being evaluated for the treatment of non-oncological indications, such as Alzheimer's disease, liver fibrosis, Parkinson's disease, psoriasis, and rheumatoid arthritis.
5,300+ patients have been enrolled in over 60 clinical trials of targeted protein degraders, worldwide
Centers in North America account for over 50% of the enrolled patient population; this is followed by Europe (34%) and Asia-Pacific (9%).
90+ agreements were inked between 2014 and 2019
Partnership activity in this domain has increased at a CAGR of close to 40%. In fact, more than 60% such agreements have been signed since 2016; majority of these agreements focused on R&D and product / technology licensing.
Over USD 3.5 billion has been invested by both private and public investors, since 2014
Of this, close to USD 1.2 billion was raised through venture capital financing, representing around 35% of the total capital raised till Q3 2019. On the other hand, there were over 15 instances of IPOs / secondary offerings, accounting for more than USD 1.7 billion in financing.
North America and Europe are anticipated to capture over 85% market share by 2030
With a promising development pipeline and encouraging clinical results, the market is anticipated to witness a rapid growth rate during the next decade. Interestingly, the markets in China and Japan are anticipated to grow at a relatively faster rate.
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Key Questions Answered
The ~USD 4.0 billion financial opportunity (by 2030) within the target protein degradation market has been analyzed across the following segments:
The report features inputs from eminent industry stakeholders, according to whom targeted protein degradation-based drugs are currently considered to be promising alternatives for the treatment of a myriad of chronic clinical indications. The report includes detailed transcripts of discussions held with the following experts:
The research covers detailed profiles, featuring a brief company overview, its financial information (if available), product portfolio details (such as status of development of pipeline candidates, clinical trial information and analysis of key trial endpoints), recent developments and an informed future outlook.
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https://www.rootsanalysis.com/reports/view_document/protein-degradation-market/289.html or email [email protected]
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